| Hugoton Gas Field | KS, OK, TX | 0.3–1.8% | byproduct | Producing |
| Panoma Field | KS | ~0.3–1% | byproduct | Producing |
| Texas Panhandle Field | TX | 0.1–1.3% | byproduct | Producing |
| Cliffside Field (Bush Dome) | TX | storage reservoir | byproduct | Storage / former reserve |
| Keyes Field | OK | commercial | byproduct | Producing |
| Petrolia Oilfield | TX | historic | byproduct | Depleted (historic) |
| LaBarge / Riley Ridge (Shute Creek) | WY | helium in ~65% CO2 gas | byproduct | Producing |
| Paradox Basin (Lisbon, Doe Canyon, Harley Dome) | CO, UT | up to ~7% (Harley Dome) | byproduct | Producing |
| San Juan Basin | NM | 0.3–0.5% | byproduct | Producing |
| Greater Natural Buttes (Uinta Basin) | UT | commercial | byproduct | Producing |
| Holbrook Basin (Pinta Dome, Navajo Springs) | AZ | up to ~8–10% (Pinta Dome, historic) | non-hydrocarbon | Producing / prospecting |
| Piceance Basin | CO | commercial | byproduct | Producing |
| Topaz Project (Pulsar Helium) | MN | 8–14.5% | non-hydrocarbon | Appraisal / development |
| Sweetgrass Arch / Kevin Dome | MT | commercial | non-hydrocarbon | Producing / developing |
| Sagebrush Project (Quantum Helium) | CO | ~2.76% | non-hydrocarbon | Appraisal |
| Galactica / Pegasus (Blue Star Helium) | CO | commercial | non-hydrocarbon | Developing |